You can find out for yourself by going back to the website your posted the link to and go to car audio and video, then select "outfit my car" and put in the year, make and model of your car, then Crutchfield will tell you what head units fit and what won't. As of right now, as far as I know, any hu replacements for the ISX50 would be considered a PIA custom install, and there are no aftermarket direct fit kits available, as the radio is seperated and other car functions are incorperated into the unit along with the voice command system and the steering wheel controls. So aftermarket comapnies would have to make a radio specifically for the IS model, as now they just make hu's and then make mounting kits for individual cars.