According to Consumer Reports, the best version of the NX is the hybrid with an overall score of 83 vs. the non-hybrid score of 72. They describe the hybrid as "more refined". They do describe the electronic interior door releases, the unintuitive gear selector, and low center dash vents as "small faults".
Fuel mileage of the hybrid is superior at 34 MPG, a 42% increase. Our RX400h cost us $50K (before tax), 19 years ago, so your $50k cost doesn't seem so bad. We get 25 MPG.