According to Consumer Reports (2021 Buying Guide), the 2014 LS460 has an overall reliability rating of "Much better than average". There are only two areas in which reliability ratings are below average:
Engine, minor: Oil or fuel leaks, accessory belts and pulleys, engine computer, engine mounts, or engine knock or ping
Drive system: Drive shaft or axle, CV joint, differential, transfer case, driveline vibration, traction control, stability control (ESC), or electrical failure
A good looking over by a mechanic (or yourself if you are knowledgeable) would be prudent. Ideally, the seller would have a complete list of maintenance and any repair work.