I'd say yes if they came off an IS. Of course the size comparison and circumference is also to be considered. Not sure what came on the SC but seems like everything should work. As far as brakes and stuff, as cars get newer, brakes seem to get bigger so everything should fit. As far as I've ever heard, all standard car Lexus lug patterns are the same. Could be wrong but I don't think so. Sure would be a nice addition though.