at 150000 mi car had developed a shimmy upon acceleration, mechanic traced it to a upper motor mount, also left CV joint seal ( replaced the whole assembly)...I avoid Lexus as much as possible use local mechanic,. Still have the transmission flare but it hasn't gotten any worse. I do have a problem with my rack and pinion ( loose) but not enough to repair yet. My mechanic says that the car should be good for 300000 mi without major problems. I have to admit I don't pamper the car, just changed the air filter ( previously just vaccummed it off), the original wipers changed at about 140000,mi, still the same spark plugs and wires. New headlight bulbs, tires, batteries, brakes. I change the oil and filter every 5000 mi.