The Lexus brand cell phone that was a dealer installed option lowered the HVAC fan speed and muted the audio system while a call was in progress.
I even connected an aftermarket Nokia CARK-91 phone system I installed in my second (2000) LS400 to mute the audio system but I didn't bother to connect it to lower the HVAC fan speed.
Even when a Lexus phone system was never installed, corrosion of the factory installed cell phone harness in the trunk can cause HVAC and audio system issues.