Last month I purchased a LS460 F Sport new. It is a great car. The only problem I have encountered is a bad mildew smell.
I took it to the dealer, and at first they implied I must be doing something wrong, but finally they admitted that this was so common that Lexus has put out a service bulletin on it. They cleaned out the mildew and replaced the cabin air filter.
According to the dealer, this is an issue with the 2013 and 2014 models. These models are programmed to run the air conditioner all the time in Recirculation mode. This is because by closing the vents to prevent fresh air from entering, it increases fuel economy, and this is one way they have employed to meet the fuel economy standards.
They recommended that when I get about a mile from my destination to switch to fresh air mode (press recirculate button twice - to go from Recirculate to Auto to Fresh). They said this would allow the car to breathe and prevent the growth of mildew. I have been doing this for the last week and have not had the mildew return. When I crank the car, it returns to Recirculate mode, so I have to do this every trip.
This seems like an odd workaround for a car of this quality. Has anyone else experienced this? Any home remedies?