After owning many different brands of vehicles and speaking to many owners of other vehicles (including Toyotas), I can say without a doubt that Lexus is the most reliable. We have not had one issue in over 52,000 miles. That being said, I must also mention that should something happen now, especially something that incurs no charge to us, I would never say that I would never buy a Toyota or Lexus again. I can't imagine why you would feel this way unless you've never owned a Mercedes, BMW, Audi, or Land Rover - all having far worse reliability.
What brand other than maybe Acura (and it is certainly not free of issues) would you switch to?