I actually own an E350 which is a tank. Slow response and the ride is floating. I had BMW's for 15 years and loved them and would not look at a Lexus. I just got a 2013 GS350 and have never enjoyed driving more. I got an "F" sport with the Mark Levinson and rear steering....holy cow! I drove the A6 and liked the car but the responsiveness was not the typical German feel that they have had in the past. A little underpowered even at the lower RPM's where the torque is supposed to be.
Now my wife drives the E350 until the lease is up and then she is going into the new "F" sport RX350. I hope they do as well with that as the GS.........