Welcome to the LOC.
I don't own a RX350 but I have driven one several times and have never found the layout of the gearshift/console to be a problem. Additionally, I can't recall anyone posting an issue with your particular concern. I think it's like many things new, for example, when I went from my 2005 ES350 to my 2010 ES350 I thought I would never adjust to the length of the gearshift shaft, It just seemed too long and skinny and thereby, "Cheap". Now I think it looks contemporary.
However, we like what we like and when your paying big bucks you should get it.
I have been using 2010 RX 350 all this time and feel that the gear knob has been designed well, keeping in mind other controls around it.