Well, after 1000 miles and about 5 weeks, here are my personal impressions of the RX 330, this is my first Lexus (first 'luxury' car, for that matter).
I'm just going to ramble on as thoughts come to mind, first, the things I especially like:
The engine is smooth as silk, I've never seen or heard an engine so quiet, I can't tell if it is running when idling.
Pretty good gas mileage, I've filled up 3 times thus far, first tank I got about 18 mpg, 2nd tank about 20 mpg, and 3rd tank is looking to be even better.
Interior is very comfortable, I don't know how it compares with other luxury brands but the RX 330 is one comfy ride, lots of leather (or leather-like material) surrounds the driver and passengers, I know some cars have leather only on the 'seating surfaces'.
Finally, the retracting steering wheel when exiting the car is a really nice feature.
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Now, a few things I don't like:
First, as some others have noted here, the acceleration is dismal, especially from a dead stop; the advertised torque is 242 ft-lb @ around 3400 rpm, but the profile (torque as function of rpm) must be very peaky, 'cause from a dead stop, it feels like I'm driving a ship (I may have been spoiled by my previous vehicle, a Jeep Cherokee w/ 4.0L engine, which has great low-end torque).
I find this car a bit difficult to back up because the view is somewhat obstructed, but the tilting outside mirrors help.
The power rear door/hatch is too slow to get to open, I have to push the unlock button (on the key fob) twice, then push and hold the power door button in order to open the rear hatch, this process takes so long that a lot of times I find myself already standing next to the car before I've finished pushing the buttons, why can't they program the power door button to unlock the door as well (so you push once vs 3 times).
The 'Homelinks' garage door opener doesn't seem compatible with the model I have (Genie screw drive), I don't know exactly what the problem is, I followed the directions (to the letter) on how to program the opener but still doesn't work.
Lastly, I don't find the (driver) arm rest very useful, it is too small to serve any purpose and not particularly comfortable, it actually gets in the way when making a turn, I'd prefer to have the center console taller, which then could function as an arm rest as well.
So, there you have it, overall grade I give the RX330 an 85/100. I bought a Lexus mainly for its reputation for reliability and resale value, as long as those characteristics hold up I'm content. Thanks for reading.