My neighbor has 22's on his GS300. Everything is stock with the suspension, but he rubs like crazy. He hasn't rolled his rear fenders either, and when he turns his wheels all the way in one direction it rubs as well. Trust me 22's are too big on the GS in my opinion. My 2 cents, 20's are the max after that it's gonna look DONK. Unless that's the look your going for, then go for it!!