I have had my 2010 RX-350 as my corporate car since August moving from a 2005 Highlander now kept as a whatever car for employees.
I love the ride and handling though miss the space and visiblity in the Toyota. As others have said, I have left the car running as I get out but now reptition is helping avoid that. I agree more intuitive placed 12V outlets would help. I basically consider the Lexus a laptop with wheels and the joystick control can be distracting especially when playing with the navigation and XM . But as a testement to the quiet and quality of the car, I go out of my way to drive wherever and whenever I can in it as I love the experience. And that pretty much says it all.
I test drove and Acura MDX, Honda Pilot, and a Murano along with the RX-350 and my choice was clear by the end of the day.