don't know enough about the 350... but your typical engine performance upgrade would be intake (not much here), header, high flow cat, mid pipe, and axle back. Then check out some engine management. but seems like Lexus has some pretty tight ECU, not sure if there is anything available for aftermarket.
force induction is always a good way to go, but not sure if there is a kit for it. even if there is, I think your CR is too high for FI. might have to run on a very low boost, then might just well not....
i am still doing research on the 350. I am all for performance, but I don't think I would pick up a 350 to mod it. I rather pick up an STi or WRX TR and mod that sucker out. :)