I have a 2011 RX350. I've used 87 octane up to 93 octane both ethanol and non-ethanol gas from virtually every brand in our area and states that we travel. I find absolutely no noticable difference in any of it. The vehicle gets about 18.5 miles to the gallon on all of it.
I have a Toyota Sienna, same engine, same thing on it except it gets about 19.5 miles to the gallon.
I also have a BMW that it does make a big difference in the octane rating and definitely runs better on non-ethanol gas.