I just had my girl's car (IS250) taken in to my mechanic for the 60k service. We did spark plugs, oil change, air filter, fuel filter. Checked the brakes, topped off coolant, and looked at the belts, and seals. The whole thing cost me $300 for parts and labor and took about 4 hours from the time I got there till I left. If you have the tools and are mechanically inclined, it is all stuff that you can handle yourself, the parts would be around $100-$150. The only hard part was removing all the bolts to move the throttle body out of the way to get to the driver side bank of spark plugs.
hope this helps