Okay, have resolution.
After cleaning the IAVC and not getting a good result, I then clean the MAF and still had codes, however after I disconnected the battery the codes went down to the #2 cylinder misfire.
Bought 3 ngk spark plugs (dealer $13.86 ea, Azone $6.99 ea) bought Azone and replaced the #2 #4 #6 plugs accross the front. Ran code check, still the #2 misfire code came up. Obvious now it must be the ignition coil for #2.
Price @ part store $87.00, dealer approx. $189.00
So I did the next best thing, went to salvage yard and bought a OEM cylinder off a low mileage salvage for $25.00.
Installed, and the RX300 is running like a charmed champion.
I think I allowed the tune-up items to go undone for too long.
I read the instructions for the sparkplug changes for the rear three plugs, and I found a new tool at Harbor Freight and Tool that will do the trick. It is a new long socket wrench, that is flat and has a t-bar internal twist handle that can reach two of them pretty easily. Gonna get it and try it, later to complete the tune up.
When I pulled the #4 #6, they looked pretty good, but #2 was fouled badly.
Thanks to the forum and all the inputted knowledge of this area.