Door lock won't turn, but key works in the ignition?

[care_mentor_288]

Hi, I have a tricky one:
- The drivers' door lock won't turn with either of the keys I have.
- The door lock doesn't budge at all. The key goes in, but won't turn even a bit, even if I jiggle it.
- The door lock and ignition are all original, the keys work in the ignition and the glove box.
- I loaned my friend the car during COVID and he said the master key fob was getting finicky so he had it duplicated, I have the duplicate, the original valet key, the metal key tag that came with the car, and the original wallet metal cutout key. 
- When I put the drivers' window up and down it sounds like the gasket at the top of the window might be loose. I don't think this is related, but figured I should mention it. 

So, I think the key not working might have to do with the electronics, but I'm not sure how to reset it.

If I open the car with the key fob then both keys work in the ignition, but neither key can open the door manually. 

I don't want to lose my master key and be out $$$$ trying to start over from scratch at the dealership.

Any advice/thoughts?

Thank you!