Purchased a 2002 RX 300 AWD and would have to say it's been a great car with no major problems. Service is done at our local dealership after a mishap with at a mom and pop oil change place *knocks on wood*.
My only knock on the Lexus would be the key fob. I've had to replace the key casing three times at $67 a pop. It's a good thing because if I lost the key it would have been $199.