I have a GS430 with factory yoko's. They lasted only about 20k. After that I figured I would upgrade the yokos to the yoko advan A10B. From the reviews at tirerack.com i figured they were going to be great. I was wrong. They are wearing fast and they have to be the noisiest tires I have ever had. I will never buy another yokohama brand in my life.
I have had the same problem, so for my 25k service I asked them to take a look at the driver side mirror. They said they needed to replace the motor for the mirror. From there after, the mirror has worked fine.