Just did the Seafoam. Here's my experience.
I put it in through the vacuum hose as shown in this thread. The Seafoam website or YouTube video by Seafoam I saw (can't remember which) also showed this as well as putting a third in the crankcase and a third in the fuel tank. Ran it and got the cloud as everyone else. Though I must say that I'm pleased in that I didn't have as much as a cloud as others I've seen. Must've been because the previous owner did take great care in the car and maintained it quite regularly as advertised.
I did that in the morning. Took it to my Lexus mechanic and had him change the oil to Mobil 1 synthetic.
Now the same day in the afternoon, I'm driving to Reno, but first to a store in Sacramento. We get off the highway and are waiting in stop-and-go on the exit. I notice that my Trac light is blinking and the Check Engine light is on. I'm thinking "Did I ruin my car?!!!" We get to the store and the lady lets me get online. This is around 6:30 p.m., I'm 4 hours drive away from my mechanic and besides he and all other repair shops are closed. (Fortunately for me.) I already checked my manual for what these lights mean and I'm now panicking. I'm wondering if I should spend the night and go to the Lexus dealer in the a.m. as I didn't want to keep driving and ruin my engine and/or tranny. So I call Autozone and they no longer get check engine light codes for free anymore (corporate and CA regulatory baloney) so the cheapest diagnostic tool is around $100. But then, what would I do with the code with no tools on me anyway?
While I'm surfing online for the nearest Autozone and any mom & pop garages that just might by chance be still open, I come up with the brilliant idea of searching for this problem on this forum! (Duh!) And lo and behold, I find a similar problem and plenty of references to disconnect the negative battery terminal for awhile and see what happens after you reconnect. THAT SOLVED THE PROBLEM! Both lights are off. Even with the lights on, there wasn't a noticeable performance issue or problem.
All I can say is THIS FORUM ROCKS! It saved me who knows how many hundreds of dollars of unexpected expense for a Lexus dealer to find out.
THANK YOU to all who selflessly share their knowledge and experience with all of us.
Oh, and I think it is cool to find out that even with the battery pulled, all my radio station presets were preserved!
BTW, I am now experiencing an increase of 4 MPG of 26 MPG, up from 22 highway. :D
Brad