Recently bought an RX330, great car, love driving it overall. It is not complaint-free however, and some of Lexus' choices just don't make sense for such a refined aurtomobile:
Road Noise - The inner cabin is whisper quiet, but on all but the silkiest of roads, you can hear a pretty consistant grind of the tires or wheels or axles, I'm not sure which...on some roads it's so grindy and tactile, it sounds like your rolling down the road on the rims sans tires. Feels cushy enough under there, just noisy, why couldn't they handle that?
No Left Leg Room - As on most Toyota products, there is an angled, rubber-padded foot support for the driver's left foot. Toyota's had this forever, my wife's '93 Land Crusier has it. Resting your left foot here, which bends your knee up, is OK for a while, but on longer trips you want to fully stretch out your leg. Can't do it, there's no space to put your extended foot. If you try extending it to the inside of the foot suport, your leg gets cocked at a funny angle and your foot ends up underneath the brake pedal, not good. You can, of course, power the driver's seat back to the point where your leg is at full extension while resting your foot on the pad, but by then you're too far from the steering wheel, which they made extendable, but not extendable enough, unless you've got Mr. Fantastic's arms. Japanese folks are short, and they seem to have trouble designing non-claustrophobic seating for the American market.
Audio/Voice Navi System Weirdness - The stock audio system that comes with the RX is mediocre at best. The EQ choices are minimal, the speaker choices are cryptic - POS FRONT, REAR, ALL, DRIVER doesn't tell you which speakers actually on or off, and even with speakers and EQ chosen for most power, it still sounds kinda canned and not like a fine audio system. My RX doesn't have the Mark Levinson, but threads here say it's still not nearly as good as a better aftermarket amp and a couple higher end speakers. I don't even know where the amp is located in this car, how much RMS power it's throwing, or where a sub-woofer is installed, if there even is one. And what's with a tape deck!!, This is 2007 for chrissake, who the heck listens to tapes anymore?! How come they made sure there was a tape deck, but neglected a simple front-mounted Aux In plug for your iPod?! The audio design dept. is obviously from another era (pre-Elvis!)
The Voice Navigation on my RX is a total disaster. There are supposed to over 100 voice commands the system easily recognizes, but Lexus makes it arcanely difficult to get a complete list, or to even identify which version you're working with. Lexus Customer Service told me I had the "latest version 4". 4 is not the latest version, there is a version 5, but they didn't tell me that. In order to get a full version 4 list, I had to search it on this forum. The list Lexus directs you to, the Help screen on the Navi System itself, doesn't even list half the available commands. Worst of all, it consistently misreads my voice commands, offering me POI icons and other crap that's nowhere near the words I spoke. And no, I don't have an accent, and I speak very clearly. Virtually useless!
This is a hot car...but this is a HOT car - In So. California and other hot climates, the ventilation system quickly shows its inadequacy. The inside of the car starts out hot on sunny days...not abnormal, but driving on a beach highway at 69 degrees outside, with windows up and AC/Recirculate off, I cannot cool down the cabin just with the regular vents open. For some reason, the air coming through the vents is decidedly warmer than the air outside, almost as if the engine is heating it up first. Opening the windows at 75mph would be too loud, and I can of course turn on the AC, but I shouldn't have to when it's only 69 outside. Toyota makes stuffy cars.
Voice your own thoughts/responses if you have 'em