Good ideas - I don't actually have a remote for the LS400, just one standard issue laser-cut key that came with the car.
So, no remote to be accidentally pushed while in pocket, and no electronic key to be dirty inside. I DO have an dual-mode analog/digital cell phone in the car, so I'll remove that from the equation in the future. And I'll need to check out different geographic locations, per ToddLS400's suggestion.
A wiring short is my biggest fear. My indie Lexus repair shop doesn't like to track down electrical gremlins, and a 1+ hr drive to the nearest Lexus dealership for an intermittent problem sounds perilous, "Sorry, but your locks are working fine, we can't seem to find a problem. That'll be $80. Have a safe drive home."
The wife's Sienna has an aftermarket keyless entry/remote starter that I installed myself, so I thought I had bungled that one somehow. But now that the Lexus is doing something eerily similar...may have to check the Toyota TSBs. Thanks for the ideas, gents. If you can think of any others, please let me know.