I have a 2000 rx300 AWD with about 66,000 miles on the truck. I have not had any transmission issues so far. I did the complete flush and fill at the 60,000 mile service. I bought the car with about 50,000 miles on it. I do not know much of the service history before that mileage. It belonged to my boss's wife who pretty finatical about the up keep, I just do not have any receipts, but it was alway serviced at the Lexas dealer where it was bought new.