In November '05 I placed an order with my Lexus dealer for an IS250RWD. It took 5 months to get here from Japan but it was worth the wait. Why order it? Well, I wanted the Mark Levinson stereo WITHOUT the Nav system and the RWD was not offered in the icy-cold climate here in the Buffalo area. So... customize and wait. The Nav system is a big waste of money. I got a TomTom 910 instead. It's sweet and I get to keep it at the end of my lease!
The 2006 IS250 is a delight to drive. The RWD handles fantastically, just like I remember my first car waaay back in High School handling. I like that 'seat-of-the-pants' feel you get from the RWD. And at 70 mph on the highway this car gets 36mpg! I'm not kidding... I've clocked it on a dozen or more trips. The overall fuel economy is around 32mpg. And the performance for a 2.5L V6 is superb, especially with the ECT switch engaged. Mountain roads ara a blast.
I drive it like you say you'll be driving yours -- barely 7000 miles to date. Watch out for the front tires wearing out early as that goes with the territory for that style rubber. Mine are showing some slight wear from hard cornering! So far no glitches with maintenance. I will note, though, if you want to use an MP3 player through the car speakers AND power it off the car's power, you'll need a noise filter. It took me a while to explain to the dealer what the issue was. When he understood and agreed it was a 'design fault' with the car, he sprang for the filter. Here's a link to the one I got:
http://www.crutchfield.com/S-MwSjhp8iMQE/c...d+loop+isolator
It works great.
One last note: I leased my IS250 for 4 years. Given your situation, I'd highly recommend you look into leasing yours. It makes good financial sense if you can get the 'right' deal. Do some research on the web and you'll find how to negotiate a great lease -- and save your cash for med school!