I have a 2021 RX350. Owners manual states to use regular gasoline rated as 'top tier'. Accordingly, I exclusively use Marathon regular gasoline. Occassionally I will add a bottle of Heet or STP fuel additives to a tank of gas. I really don't know if there's any benefit to using the additives. Also of note, I do not live in a cold weather climate. I use Heet occassionally because it is supposed to eliminate any water in the fuel. Comments/suggestions are welcomed.