The only annoyances I have is opening the door and not always pressing the button long enough so I can open the door and the brakes. I have had Lexus hybrids since 2012 and braking is definitely different from the standard cars. The NX braking definitely takes a bit of getting used to.
On a positive note, my overall mileage since I purchased it is greater than 40.4 (bounces between 40.4 and 40.5). I don't use economy or sport. Its a bit hilly where I am but I still do well.