I've had a 2013 RWD GS350 for about 2 months. While I like it overall, I think the cooled seats are far worse then the 2012 ES loaner car I was driving. I live in Texas and I can barely feel the air flow on the seats and I'm certainly not "cold" while driving. The main vents, those are freaking cold.
Other minor dislikes: don't park the car in ECO mode as there will be a long delay to get the A/C going.
I think the voice recognition is terrible. As far as apps/phone, I have a Blackberry, so I am doomed for failure there.
I have the Mark Lev, but I feel that using the wheel audio controls or mouse is more cumbersome than having push-button pre-sets. With satellite radio, HD radio, and 6 sets of presets, clicking one at a time with the mouse or wheel is a huge pain.