Just recently had this problem with a 99 Lexus RX300. I read the online posts and by far the most successful trick is tapping the key while in the ignition. Approximately three times with a hammer is about all it takes. Depending on what type of key you are using, be careful as you could then crack the remote casing. WD 40 works occassionally and so does patiences, as evidentially it will give. I ran out of both and the hammer was a nice option. According to High Tech Locksmiths, which recommend the two top options above. They explain that its a tumbler within the ignition that hangs and fails to drop in place for your speciality laser cut key. We are replacing the ignition at this point as the problem continues to happen more often, especially it seems in colder temperatures.