I have a 2008 GS350 with the same problem. It seems to happen when the car sits in any kind of heat. If the radio is left on, before the car is turned off, once started, the radio becomes hard to turn off and vice versa. I have taken the car to the dealer twice over the past 14 months but they cannot determine the problem. I spoke with an outside technician and he thinks it could possibly be a computer glitch.