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I do wipe the leather seats with conditioner once a month and I do run full synthetic oil. I only use top-tear premium gas ( in the US only the best gasoline is able to carry that label ) Consumer Reports said it was worth the difference. I also use Lexus touch up paint each spring to cover any rock chips. 

My 2006 RX 400h has almost 275,000(274364) and it still works perfectly. ALL the original equipment is working and the original hybrid batteries are still working fine. Gas mileage is still 26/gallon and I have only done the normal 5000 mile checks at the Lexus dealership. We are planning on about 10,000 miles of trips this year with it. This is the first vehicle I have taken over 100k miles that still has all the equipment working and no leaks.