I bought a LS 460 in July 2008 and the rancid, sour-milk-dirty-wet-socks-vomit smell began spewing from the vents when the A/C is on about 6 months into ownership. It only happens for about 15 - 20 seconds, but when it's blasting forth, it's enough to gag you. I have had the car at the dealership service department 3 or 4 times since then. They can never recreate the problem (which stuns me because now it happens almost every time I turn on the A/C). In the past, they've told me to leave my car windows down while the car is parked overnight in the garage. No help. They've advised me to run A/C on outside air, rather than recirculate. No help. This past winter, it also happened when my heater was on.
Today, I was told that because I have children, the bad smell was coming from the car itself, and that it needed to be detailed. Wow. Yes, apparently, when the A/C is on, and it's on recirculate that simply brings the air from the back of the car, where the children are, up through the vents! I don't even know what to say. I have a call into the General Manager and Lexus Corporate. Then I came here and saw this conversation. My stinky children and I are thankful for this forum.