Just got the car back with the new (used) transmission. The whine is greatly reduced with this transmission but it is still audible under accelleration above 70mph. It is better but for a $70K car it should not be there at all. It is definitely a problem with the 6th gear od and the design/manufacturing tolerances. I rarely listen to the audio system so it probably effects me more than most. I am sure that Rush wouls drown it out.
My advice is drive any 2004 LS430 at 70-85 before you buy and see if it has the problem.
Otherwise, I love the car and Lexus has tried to solve my problem.