bdhill390,
I've accidentally done gotten the tires to break loose in my wife's ES - a few times on the old tires. There is a spot on the way to work at a stop sign, going uphill so whenever the roads were slick, it was drift-city :) I used to drive a few American Muscle cars, so it was kind of fun at the time but, of course the Lexus does exactly what it's supposed to and immediately corrects the situation, but hey, that's why they're such amazing machines.
Aside from that, keep in mind anytime you're racing someone else or just playing around, the better the tires stick to the road, the more power you transfer to the pavement (which is why this car is so peppy and you can pull away from most of the other street cars pretty easily in the GS)