Hands down, not even close, the IS300 handles better. I've owned both, so I'm speaking from experience. The SC300 does ride smoother, mainly because the IS300 is built on a performance chassis. In fact I would have to say that the IS300 is the best handling stock car on the road today. I've driven most of the upper end cars that are known for handling (911, M3, STI, etc.) and I'll take my IS over any of them.