Folks safely put wheels on cars with far more torque than the RX puts down. I would be looking at forged wheels to keep the weight in check. Just about anything else is going to be heavier than stock. The el cheapo wheels are tempting but can weigh in at 5 or more lbs per wheel more than the stock pieces. Unsprung weight is detrimental to performance in every way, hurting acceleration, braking, handling, economy, and ride. The penalties are greater on a hybrid than a standard drive. If you want to go to a different size solid research would be in order to determine what you might be running into. Remember that the power distribution scheme was designed around the stock wheel sizes. There is also the usual stuff like speedo accuracy that need to be taken into account. Sticking with the stock wheels size and offset or very close to it (normally OEM specs allow around 3% to account for tire wear and inflation) will be best if you want a hassle free experience.