I have a 2007 GS350 with Nav. If you have the "regular" Lexus audio system you can only play CD's or CD-R's. I have the Mark Levinson Audio system and it lets you play CD's, CD-R's, DVD-Audio and DVD Videos.
I hope this helps.
Do you like the car?
I have ML stereo but I tried multiple different DVD-Video discs but it only plays the sound without the videos... There's a "picture" button but it is not pressable when I have DVD discs in it. What kind of DVD-Videos does it play?