After twice replacing the Dunlop OEM tires on my 2006 GS 300 due to them waring down quiclkly and a terribly rought ride (one time the dealer split 50/50 with me, the next time I had to buy them), I put Goodyear Eagle Repsonse Edge Tires on my car... at 27,000. The car was transformed. It drove quietly and much more smoothly than with the OEM tires, however, when I took a turn hard, drove in the rain, .. the tires gripped the road very well. I now have 64,000 miles on my GS, with the SAME SET OF TIRES... which are now ready to be replaced. I would highly recommend these tires.
On another note, either my shocks are going bad or my suspension is failing, as even a small ripple in the road makes nosie and a slight shudder.