You can do a quick and easy check to see if your wind noise is caused by the the black plastic triangle in front of your side view mirror. Just seal the black triangle by putting masking tape around all 3 sides and take it for a highway drive and see if that makes any difference. It made no difference in my car, so that wasn't the cause of the problem.
Most 2008 LS460/LS460L were factory-equipped with laminated (Lamisafe) front side glass. All 2007 LS460s were made with tempered glass only. Part of the wind noise fix for the 2007 LS460 includes the addition of laminated (Lamisafe) glass to the front windows, replacing original tempered (Temperlite) glass.
Several days ago, I took my late production 2007 LS460 in to replace the recalled fuel line and also complained about wind noise from the driver's side window at highway speeds when the glass was in the full up position. To reduce the noise, I had to tap the window switch and move the glass down slightly but it was still a little noisy. Without hesitation, my dealer (Nalley Lexus, Roswell GA) replaced the driver's and front passenger glass under warranty and explained that the new laminated glass seals better because it is slightly thicker than the original tempered glass. That made a huge difference, and my car is now much quieter at highway speeds. And I'm a very satisfied customer. :D
stuart: my glass was replaced with the laminated windows etc around one year ago. but suddenly, last month, the symptoms spontaneously reoccurred.im afraid its not if your wind noise will reoccur, but when its going to reoccur!