It's water in the spark plug holes... Around the engine there is a plastic covering where it says "V8 4 CAM 32" that covers the spark plug holes. While it does have a rubber gasket on the edges, two things are possible, 1. It wasn't installed properly so the gasket doesn't seal tight, letting water in. 2. The design is crap and no matter how it's installed, water will migrate into the spark plug holes, causing the plugs to short to ground, therefore causing a misfire.
I felt compelled to chime in because this was an issue that stumped me for some time and I didn't figure out the problem until I stumbled upon a video on youtube discussing cleaning engine bays of Toyotas/Lexus vehicles and how water likes to get into the spark plug holes.