I've always considered dropping the RFTs but being cheap, I was waiting until they were nearer to the end of their useable life. That is, until last weekend. I was driving on a highway and had the air pressure alarm go off. Sure enough, when I pulled over and checked the tires, the right rear was at zero.
Being only about 25 miles from my dealer, I decided to limp over and get the tire fixed. WRONG! After about 12 miles the tire started to disassemble itself. I had to call Lexus towing and wait over an hour to get towed in. I no longer trust the RFTs to get me anywhere in case of puncture. The Lexus dealer informed me that there is no actual warranty for how long the RTS will hold-up and he thought 12 miles was pushing it!
From reading the many posts here, and my own research, I already knew I would buy Michelin Pilot Sport A/S tires, so I ordered 4 from Tire Rack and had them delivered. Picked the car up on Saturday and all I can say is DON'T wait to drop the RFTs! I can't believe the difference in noise, handling, and comfort with the new feet.
BTW, I also purchased a 12V compressor/fix-a-flat combo unit from Tire Rack. I'm sure I'll get better than 12 miles if I ever get another flat. It's called CONTI COMFORT KIT-12V PORTABLE and costs $79.
Add my voice to the pack.... don't keep the run flats!