I was looking at the RX350 and the Highlander's websites and it was interesting to me actually how close they are in price when you compare option for option. However, there are quite a few options that you just can't even get on the Highlander that you can on the RX350, like HID lights, Bluetooth Nav, and the awesome Mark Levingson stereo, not to mention the window roll down feature. Personally the RX just looks better inside and out than the Highlander. I wouldn't really consider either to be much of a "utility" SUV, but I don't really think that is why you shop in this segment. Our 01' RX300 is really for my wife, and although she is really not a snob (really) she does prefer a Lexus over a Toyota (and we've had 2 Camry's, a Supra, and a couple of pickups to compare - oh and an EB Ford Explorer). It's hard for one person to tell another what to buy, but if it was me and price was not factor - RX350.