All, just wanted to chip in since there are so many helpful comments here. A wrong Lexus key was inserted into my IS300, resulting in my key not being able to turn at all. I use the spray lube, dry variety, and still no luck. My mechanic buddy suggested I use a straightened out paper clip to move things around in the key hole, and voila! It was such a simple thing to try, and I worked, so I wanted to share that with you all.