I am picking up a 450h at the end of next week so I don't have any experience with it in the snow. I have driven a LS 430 for four winters in Chicago. I was pleasantly surprised how well it handled in the snow. I suspect that the 450h, with extra weight over the rear axle and decent all season or snow tires, should perform similarly. I agree with the others above that the tires are key.
Enjoy your 450h!