My 99 RX300 has 218000 miles. I just changed the TB, water pump and seals (second time) The only problem I am having is at idle the A/C cuts on and off. I probably have to clean the idle control valve. Major repairs over its life were, a new "brain", exhust manifold, 2 cat converters, window control switch drivers door and the ignition lock. Trying for 300K.