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If all these codes appeared at the same time it would seem they have a common cause such as a bad connection in the coil harness or the fuel injection harness. Ignition coils are a common problem with this generation RX but they would fail individually. Fuel pressure is another common source that would cause multiple misfires simultaneously. Here is a link which discusses the P0300 code for your Lexus and that might help. https://www.autocodes.com/p0300_lexus.html#disq I also would not discount the camshaft position sensors or the crankshaft position sensors as they can also create havoc with the engine control system. Given the age of the vehicle and the mileage you should think carefully before throwing a lot of money at the vehicle in search of the cause and then the repair. Good luck.

I bought a 2012 LS460 in February 2020 with 87K miles and have all the service records. Control arm bushings, alignments, 3-part fuel service (induction cleaning) and other typical 5K service charges were the charges to date. I don't see any transmission or differential fluid changes yet. I took it in for the 90K service and it cost me $900 (incl. $600 labor for 2 hours) OUCH! Guess I should have known this is a rich man's car. I'm trying to find out what the typical ongoing, high-cost repairs are over the next 3 years. A neighbor has one with 180K miles and nothing major yet.

I don't see changing the transmission and differential fluid in the maintenance schedule for the 2008 LS460. Lexus dealers like to make money by doing unnecessary services which was one of the reasons I rarely used Lexus dealers for service during my 24 years of driving LS sedans. I see that engine coolant (120 months) and brake fluid (180 months) could be past due or due to be changed based on time instead of mileage. If you are going to be conservative, those might be services to have performed ... or maybe not. Ask the dealer service writer where in the heck something called induction system cleaning is specified in the maintenance manual. That sounds like a totally bogus trumped up service. Here's a link to the maintenance manual for the 2008 LS460: https://drivers.lexus.com/t3Portal/document/omms-s/L-MMS-08LS460/pdf/L-MMS-08LS460.pdf