While I too, have over 100,000 miles on my 2004 RX330 (125,000), I attribute this as much to my maintaining the vehicle as much as Lexus quality. I've had quite a few other brands over the years that have gone over 110k.
I have had this car in the shop more than any car I have ever owned. Transmission, mirror falling off, exterior window trim fell off, brakes shimmying etc. etc.
Presently, the roof rattles like crazy at highway speeds, the paint is chipping like mad on the front, all the dash warning lights come on at once periodically, the buttons fall of which hold the glove box in place etc. etc.
I highly regret having bought this car, at over $40k.