I bought my 2000 ES300 in 2006. Since then, I have replaced (2) A/F O2 Sensors, (2) Knock Sensors, (1) Coil pack on #2 cylinder, Window regulator/motor front passenger side, IACV under throttle body, (1) top and front engine mounts and (4) shock struts (I did my own work). I had the timing belt replaced for $500.00 and replaced four tires 2x since then. The hards job I performed was the Knock Sensor, took me 8 hrs and $320.00 in parts. http://us.lexusownersclub.com/forums/index.php?showtopic=30723&hl=
My wife is happy with this reliable car. She drives it everyday 40 miles per day to La Jolla, San Diego ca.