Sometimes, not always, at highway speed over 60 mph, I get wind noise from my window. If I open and close it, it sometimes gets better. Any ideas as to how to do a permanent fix?

Thanks,

Hank

Much has been written on this matter. Do a Google search for LS460 wind noise tsb (technical service bulletin) and read all about it.
I had all the factory fixes done on my 2007 LS460 (new laminated glass, etc) and it made a big difference, but there is some occasional wind noise above 60mph in a crosswind. Your 2008 was manufactured after the VIN #s affected by those TSBs. Try putting masking tape around the black triangular plastic trim piece next to your outside mirrors to seal the gaps and see if that makes any difference. Complain to your dealer; that worked for me.

Most of the wind noise fix has been discussed on other lexus forums. try searching for jmcrany wind noise fix.