Background: My IS250 has the Staggered Fitment OEM 18" wheels. I purchased my set of Nitto Invo tires in October of 2007. They replaced the OEM Bridgestone Potenza RE050. I purchased these tires due to their non-directional tread design which allows rotation side to side. The OEM Bridgestones became very noisy after 10K miles and I had Lexus replace the front set due to a loud "Waa-Waa-Waa" sound that developed in them (Lexus paid for the new front set and a front end alignment). After another 10K miles this second set developed the same "Waa-Waa-Waa" sound. So I was looking for a tire that was quiet, could be rotated side to side, had good handling and wet traction.
25K Mile Update: I now have 25K miles on my Nitto Invo tires. They were extremely quiet when new and are still very quiet after 25K miles. I rotate them every 5K miles with the Oil Change. My driving style is average - not too agressive, mostly on winding rural highways. I would rate their Handling as good on both Dry and Wet roads. Approximatly 40% of the original Tread Depth is remaining, so I estimate a 45K mile tread life. The main reason for choosing these tire was a Quiet Tread that would stay quiet, and the Nitto Invos have definetly done this. For my basic driving style they handle very predictably, solid and sure in corners.
Bottom Line: Very quiet, good handling. When these wear out I will be buying another set.